Since you said you like The Binding of Isaac, you could check out other roguelike games. Now for something in that genre that would be either exclusive or better on PC, you could try out Enter the Gungeon; it exists on other platforms too, but I prefer playing it with mouse and keyboard.
As people have been saying, most games that would be exclusive or PC-staple kind of games are usually strategy and simulator games (like the ones that have been mentioned, i.e. Kerbal Space Program, Minesweeper), so you could try out and explore those genres.
Personally I've been oddly addicted to Euro Truck Simulator 2 lately. It is exactly what it sounds like.