Right now on Wii, I'm rotating between: Okami, Lost in Shadows, and Wii Sports (because it's too cold to workout outside).
I'm currently taking a hiatus from my GBA games because the ones I am playing suck up so much time and I have to focus on school, but I was alternating between Final Fantasy VI and Golden Sun: Lost Age.
On my DS, I recently beat Sonic Rush and I've given up on The Legend of Zelda: Phantom Hourglass (I hate the main dungeon).
On my PS2 I'm currently playing the first Kingdom Hearts
On my husband's PC, I'm currently playing Dragon Age: Origins, but it's kind of a pain because I have to kick him out of his computer every time and I'm honestly waiting for my tax returns to come in so I can get myself a decent PC that doesn't crash anytime I want to play Portal :P. Yeah, my current PC sucks.
On my PS3, I want to get the rerelease of Ico and Shadow of the Colosus and play those. I also want to get Final Fantasy VII and VIII from PSN and play those.
On the 360... well, that can sit there and gather dust at the moment. I will probably use it whenever I get Marvel vs Capcom 3, though. I like the 360 controller better for fighting games than the PS3 controller.