I'm a big fan of webcomics, too. Since discovering how awesome they can be, my list of comics I read regularly (or follow, in the case of comics with continuing storylines) has picked up and dropped content. My current list is below, including brief descriptions (of those not already mentioned by someone else in the thread, anyway).
- Ctrl Alt Del
- Looking for Group
- Megatokyo
Set in a fictional version of Tokyo, Megatokyo portrays the adventures of Piro, a young fan of anime and manga, and his friend Largo, an American video game enthusiast. Piro's adventures tend to be mired in complicated relationships, while Largo's tend toward the more fantastical.
A comedic webcomic that celebrates and satirizes tabletop role-playing games and medieval fantasy through the ongoing tale of the eponymous fellowship of heroes. Taking place in a magical world that loosely operates by the rules of 3.5 edition Dungeons and Dragons, the comic follows the sometimes farcical exploits of six flawed adventurers as they strive to save the world from an evil lich.
Erfworld follows a graphic novel format, with a new page added with each update. The setting is Erfworld, a fantasy world that adheres to the rules of a turn-based strategy wargame. The narrative focuses on a complex story about warring factions within this world, but most installments also contain humor about strategy-fantasy video games, role-playing games, and references to history or popular culture. There are frequent puns and side-gags.
Goblins - Life through Their Eyes is a Dungeons & Dragons webcomic written and illustrated by Tarol "Thunt" Hunt. It is set in a humorously stereotypical fantasy setting, and follows the lives of a party of goblin adventurers who started as monsters and declared themselves player characters. The tagline for the comic - "Life through their eyes" - reflects the predominant theme of the comic: telling a heroic tale of creatures normally viewed only as evil and weak.